1500s — Spanish explorers arrive in Yakni, or "fruitful earth," as the Native Americans call the Marion County region.
1792–1809 — John Ford's home is built with a stockade at "Fordsville," near the Pearl River at Sandy Hook.
1798 — April 7. The Mississippi Territory (Mississippi and Alabama), seen by pioneering families as "The Garden of Eden," becomes an incorporated territory of the United States.
1805 — John Lott Jr. settles on the east side of the Pearl River. The place is named Lott's Bluff, later renamed Columbia after Columbia, South Carolina, from whence many pioneer families came.
1812 — December 26. One of the first post offices in the territory is established at the Ford House, a major intersection of the post roads.
1814 — November 27. General Andrew Jackson stays the night at the John Ford Home on his way to the Battle of New Orleans, with his militia and Choctaw Indians.
1816 — The Pearl River Convention meets at the John Ford Home to draft a resolution for Mississippi statehood.
1817 — December 10. Mississippi becomes the twentieth state in the Union.
1819 — June 25. Columbia becomes the fourth incorporated municipality in Mississippi.
1821–1822 — From November, Columbia serves as the temporary capital of Mississippi.
1822 — The state legislature meets at the Stovall Spa Mineral Springs Hotel, three miles north of Columbia. The decision is made there to move the capital to Le Fleur's Bluff — what is now Jackson.
1859 — Mississippi becomes the leading cotton producer in the United States.
1904 — Mississippi's timber boom begins. Towns like Columbia prosper along the rail lines supporting the lumber mills, and Mississippi becomes third in the nation in lumber production.
1936 — Columbia's Governor Hugh White establishes the BAWI program, "Balance Agriculture with Industry."